Dr Bruno Reversade

Bruno Reversade

Principal Investigator, Human Embryology
embryo, twinning, cloning, human, development, birth defects, genetic diseases, ethics

Email: bruno.reversade@imb.a-star.edu.sg

Biography

Trained at the Pasteur Institute in Paris, Bruno Reversade obtained his Ph.D. from the University Pierre & Marie Curie in France. Whilst at the Howard Hughes Medical Institute in UCLA, he investigated the role of secreted proteins mediating embryonic patterning.

Dr. Reversade published landmark papers that provide an explanation for how embryonic homeostasis is maintained and how, from one egg, identical twins can be produced.

Dr. Reversade’s current research involves rare human pedigrees which suggest that the birth of monoclonal humans (identical twins) may be genetically-triggered. His work is engaged on sound theoretical groundings and is supported by the Branco Weiss Foundation, whose mission is to bridge Science and Society.

Dr. Reversade was awarded the prestigious, first A*Star Research Investigatorship. He joined the IMB as Principal Investigator in January 2008.

Representative Publications

1. Reversade B, Escande-Beillard N, Dimopoulou A, Fischer B, Chng SC, Li Y, Shboul M, Tham PY, Kayserili H, Al-Gazali L, Shahwan M, Brancati F, Lee H, O'Connor BD, Schmidt-von Kegler M, Merriman B, Nelson SF, Masri A, Alkazaleh F, Guerra D, Ferrari P, Nanda A, Rajab A, Markie D, Gray M, Nelson J, Grix A, Sommer A, Savarirayan R, Janecke AR, Steichen E, Sillence D, Hausser I, Budde B, Nürnberg G, Nürnberg P, Seemann P, Kunkel D, Zambruno G, Dallapiccola B, Schuelke M, Robertson S, Hamamy H, Wollnik B, Van Maldergem L, Mundlos S, Kornak U. (2009). Mutations in PYCR1 cause cutis laxa with progeroid features. Nat Genet 41(9):1016-21.

2. Abreu, J. G., Ketpura, N. I., Reversade, B., and De Robertis, E. M. (2002). Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β. Nat Cell Biol 4, 599-604.

3. Oelgeschläger, M., Kuroda, H., Reversade, B., and De Robertis, E. M. (2003a). Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos. Dev Cell 4, 219-230.

4. Kuroda, H., Fuentealba, L., Ikeda, A., Reversade, B., and De Robertis, E. M. (2005). Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation. Genes Dev 19, 1022-1027.

5. Reversade, B., Kuroda, H., Lee, H., Mays, A., and De Robertis, E. M. (2005). Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos. Development 132, 3381-3392.

6. Reversade, B., and De Robertis, E. M. (2005). Regulation of Admp and Bmp2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field. Cell 123, 1147-1160.

7. Kimelman, D. and Pyati, U. J. (2005). Bmp Signaling: Turning a Half into a Whole. Cell 123, 982-984.

8. Lee, X. H., Ambrosio, L. A., Reversade, B., and De Robertis, E. M. (2006). Embryonic Dorsal-Ventral Signaling: Secreted Frizzled-Related Protein as Inhibitor of Tolloid Proteinases. Cell 124, 147-159.

9. Sanders, V., Reversade, B., and De Robertis, E. M. (2007). The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. EMBO J. 26 :2955-65.

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